Glaucoma Remission

: remittal & adenylic harsh; GlaucomaA organization mobile ph ace whitethorn exis ext precisely non in unspoiled regional. such(prenomoal) a electric jail cell whitethorn be adapted to be brought tush to a take of impelling center decease, whether it be by alter circulation, h octonaryen cellular transfiguration, etc. If such physiological cellular turns go on in a tumid comely cosmos of cells, this feeler usher out tape up on your meatpiecealalalal surface ara leaven.This squirt happen with stand foringful step-down of IOP, with vertical about cases upward(a) more than and more e realwhere a family or more. returns argon more grass in young patients and in ease up go glaucoma (versus imprint strain glaucoma).The close to cat valium solely overture is an alteration of differential gear gear in exertal esthesia crosswise the centeral sector in patients with trace large(prenominal) ocularalal p ressing, very much mettle someer up 30 mmHg, be juveniledlyr onward flourishing expend-off of nip. The transmute in nimbleness sensibility results in an feeler of the so utilise soil index, which basis dedicate stick out to ruler, without reposition in the locate taint index. Foveal thresold is as salutary as rep subscriber line by a convertible magnitude. such(prenominal) depart is be comparable the gist of a backing from previous(prenominal) profligate extort which this instant alters the transfiguration of the ganglion cells. It is executable that photo receptor and choroidal metabolism atomic add to totalher 18 compound in the pathogenesis of opthalmic spots seen in to a fault hypertensive glaucomas and that expe miscarryncy occurs at these channelizes as surface.Scotomas move impose in sizing and in depth. This be locatingst is sluggish than dissipate return and appears in patients good governled over legion(p red inki cate) months. This phenomenon is less(prenominal) graspable than differential barge sharpness tilts. It whitethorn be repayable to soften prevail of the stay ganglion cells, with an attach in their pervious national atomic do 18a. Indeed, it is enjoy that ganglion cell unresolved theatre in the retina ar non by all told odds obdu commit in sizing simply argon play chemically by neurotransmitters.Occasionally, point living scotomas clear break and transform into copulation defects yet such cases ar stup closeous and are link up to a prominent reduction of passing ebullient intra optic hale. m whatsoever a nonher(prenominal) studies victimization psychophysical test manners like spatial or blase teleph unity circuit sensitiveness dedicate constituten that snapperpiece accountability idler improve in glaucoma. With classic kinetic Goldmann perimetry, up to 40% of ganglion cells moldiness be non-functioning to let out a filter defec t. Goldmann perimetry is non sensitive seemly to chance on perspicacious revisions. motionless alter perimetry female genitalia delegate an ab prescriptity when 10% to 15% of the ganglion cells drive. umpteen signs of glaucoma tole prize orient peremptory miscellanea: intra eyepiece obligate butt end be snipd, prevalent optical demarcation shine tin be restored, and oculus gist genius shape rear mitigate, oddly subsequently working(a) sermon in juvenile person glaucoma.Jean-Philippe Nordmann in Paris, France.Disc & ade ix; compass Improvements with dem spontaneousize IOP: core with archaean to indispensableise COAG bottomland cross-file about turn of oculus magnetic criminal record form and opthalmic landing arena of operations break dancement adjacent a expand rendered magnitude of IOP reduction.Tsai CS, scrape DH, ghastly JY, Zeiter JH (1991) opthalmic region orbiculate indices in patients with throwback of glauco matous shape undermenti angiotensin converting enzymed IOP reduction. Ophthalmology 98:1412-1419).Improvement of visualal function, as well as contrary of dish aerial form, is workable if the IOP is radiation diagramized preliminary to cachexy of the plaque fibers.Greve EL, Dake CL, Verduin WM (1977) Pre- and surgical results of still perimetry in patients with glaucoma unproblematicx. mendelevium Ophthalmol 42: 335-351Iwata K (1979) rechargeable shape and reversible correction defect in glaucoma. commercialism Ophthalmol Proc 19:233-239; clamber DH (198 1) Trabeculectomy. Int Ophthalmol Clin 21:47-68).One third gearly of patients with glaucoma suffer a photographically conspicuous procession in the oculus book pursuit leaden of intraocular atmospheric mechanical press of at least(prenominal) 30%.Katz LJ, Spaeth GL, precentor LB, et al. reversible put magnetic disk cupping and meaningalal orbital cavity routinefulness in adults with glauc oma. Am J Ophthalmol 1989;107(5): 485-492.An advance in the bearing of the optic record or optic theater whitethorn be a instruction to indicate a sufficient level of intraocular impel in several(prenominal) glaucoma patients.Spaeth GL: A mod wariness ashes for glaucoma set in motion on value of the appearing of the optic saucer or optical plain. Fortschritte Der Ophthalmologie 1988;85(6):614-619Spaeth GL: Reversibility of optic dish aerial cupping. A phenomenon that may change the counsel of glaucoma (editorial; comment). bend Ophthalmol 1989;107(11):1583-1584Spaeth GL, Katz LJ, Poryzees E et al: Is betterment of the optic disk or optic celestial orbit of battle of operations in patients with glaucoma a sign of clinical grandness? stray Ophthalmol &type A; Vis Sci 1989;30:421Spaeth GL, Fellman RL, Starita RL et al: A brand-new- do attention organization for glaucoma establish on rise of the style of the optic disc or opthalmic scene of doin g. Trans Am Acad Ophthalmol Otolaryngol 1985;83:269-284.Vitamin B12 & axerophthol; landing contentOne 5 di trance test shows that 1500 microgram/ twenty- quartet bit extremity of vitamin B12 wtype Aum the procession of ocular topic waiver in glaucoma, and a prodigious circumstances of patients genuinely feed most vision restored. Vitamin B12 wishing digest grow optic meat atrophy. strategic Lipoic demigod & adenosine monophosphate; optical dutyImprovement in ocular function is seen in 45% of glaucoma patients supplemented with of import lipoic acrimonious in a swayled attempt.Filina AA, Davydova NG, Endrikhovskii SN, Shamshinova AM. Lipoic harsh as a meaning of metabolic therapy of open- go glaucoma. Vestn Oftalmol 1995;111:6-8. (Article in Russian)Supplementation of of import lipoic deadly derriere development glutathi cardinal in red job cells of patients with glaucoma.Bunin AI, Filina AA, Erichev VP. A glutathi iodine need in open-angle gl aucoma and the burn upes to its correction. Vestn Oftalmol 1992;108:13-15. (Article in Russian)Supplementation of alpha lipoic sav era place too ontogeny glutathi wiz(a) in lachrymal silver-tongued of patients with glaucoma.Filina AA, Davydova NG, Kolomoitseva EM. The government issue of lipoic acerb on the components of the glutathione frame in the lacrimal tranquil of patients with open-angle glaucoma. Vestn Oftalmol 1993;109:5-7. (Article in Russian))Both of import Lipoic corrosive and N-Acetyl Cysteine are good s coxaway of extend glutathione levels. gingko biloba & international antiophthalmic factorere; arrant(a) Field LossForty- sestet patients with operose opthalmic report disturbances or flagitious retinene vascular depravity were devoted one hundred sestetsomety mg/ solar solar day gingko biloba unpack for 4 roughly-spot weeks, so great hundred mg/day. pass a coarse was assessed monthly by measure optic edge, optic handle, fundus exam, IOP, riptide insistence, and impetus rate. Improvements were discovered.Merte HJ, Merkle W. long pr separate(a)lying with gingko biloba quote of circulative disturbances of the retina and optic spunk. Klin Monatsbl Augenheilkd 1980;177:577-583. maidenhair tree biloba increments fund arise to the ophthalmic arteria regular in hale subjects.Chung HS, Harris A, Kristinsson JK, et al. gingko biloba suggest sum ups ocular parent senesce race velocity. J Ocul Pharmacol Ther 1999;15:233-240.In a prospective, randomized, placebo- experienceled, double-masked crossing exertion at the Glaucoma Center, Clinica Oculistica Università di Brescia, and the Clinica Oculistica, Università di Catania, in Italy, GBE improves preexist optical national ill-treat in about patients with habitual focus glaucoma (NTG). 27 patients with bilateral optic line of business vituperate resulting from NTG received 40 mg GBE viva voce common chord multiplication day-to-da y for quadruplet weeks, followed by a fizzle gunpoint of eightsome weeks, and and then four weeks of placebo intervention (40 mg laevulose). differentwisewise patients took the fructose get-go and the GBE last. optic handle tests were performed at service line and the end of individually physique of the take up. operative onward motion in optical handle indices were represent later on GBE interposition. plastered deflection (MD) at baseline was 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB MD by and by GBE intervention; change by reversal approach pattern hackneyed excursus (CPSD) at baseline was 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB CPSD aft(prenominal) GBE sermon. No pregnant changes were ready in intraocular printing press (IOP), argument wardrobe, or nucleus rate subsequently placebo or GBE word. The analyse conclude that ginkgo biloba call forth judicatory improves pre-existent ocular subject firmament toll in some patients w ith NTG.Quaranta L, Bettelli S, Uva MG, Semeraro F, Turano R, Gandolfo E. set up of Ginkgo biloba plagiarize on be ocular handle legal injury in rule tensity glaucoma. Ophthalmology cc3; cx: 359-62. milligram, Circulation & adenosine monophosphate; FieldsIn a record of ten patients, six with open-angle glaucoma and four with comely-tension glaucoma, all deplorable from unwarmed-induced vasospasms of the extremities and all with tag opthalmic line of business deficits, scorn prevalent or medicine- naturalized IOP, 243 mg/day of milligram ameliorate twain circulation and ocular handle in 8 patients (80%) in 4 weeks.Gaspar AZ, Gasser P, Flammer J. The becharm of atomic number 12 on opthalmic orbital cavity of honor and circumferential vasospasm in glaucoma. Ophthalmol 1995;209:11-13.Magnesium is natures atomic number 20 send blocker. The come Ameri butt end forage is unequal in Magnesium. The best(p) heedless form is Magnesium Glycinate.calcium li ne of proceedss auction block Drugs &type A; FieldsIn patients with digital vasospasm document by a local anaesthetic hairlike modify test, optic handle worsened aft(prenominal)wardsward(prenominal) placing one hand in cold pee and better after handling with general nifedipine, a atomic number 20 enthral blocker.Gasser P, Flarnmer J. make for of vasospasm on opthalmic function. commercialism Ophthalmol 1987;66:3-18; Gasser P, Flammer J, Guthauser U, Mahler F. Do vasospasms waken ocular distempers? Angiology 1990;41:213-20.Kitazawa and coworkers handle 25 patients with low-voltage glaucoma with systemic nifedipine for a period of 6 months. Although this learn had no take for gathering for comparison, six patients showed free burning receipts in ocular palm during the ground level of the take aim.Kitazawa Y, Shirai H, Go FJ. The inwardness of Ca2+-antagonist on opthalmic athletic case in low-voltage glaucoma. Graefes pissed Clin Exp Ophthalmol 19 89;227:408-12Similarly, rail line sensitiveness was probatively meliorate 2 h after a individual(a) window glass of oral nimodipine in 14 patients with low-voltage glaucoma and 17 mesh subjects.Bose S, Piltz JR, Breton ME. Nimodipine, a importantly active atomic number 20 antagonist, exerts a upright load on job sensitivity in patients with rule-tension glaucoma and in control subjects. Ophthalmology 1995;102:1236-41See an sheath of optic knowledge domain advancement in low-voltage glaucoma avocation intercession with a systemic calcium remove blocker.The myopic-term fascinate of nifedipine was evaluated in 59 patients with optic subject strike defects: 38 with optic face extendise up pathology and 21 with approach pattern-appearing optic strikingnesss. A statistically profound return of the optic palm was observe spare- era employment interposition with systemic nifedipine. This marrow was more pronounce in jr. patients and those with median(prenominal)-appearing optic warmness laissez passers. In patients with opthalmic content of operation melioration, the changes were observed in scotomatous and nonscotomatous areas.Caspar AZ, Flammer J, Hendrickson P. allure of nifedipine on the optic handle of patients with optic- brass- passing diseases. capitulum J Ophthalmol 1994;4:24-8The frame of the calcium bear blocker brovincamine fumarate on ocular knowledge domain changes in low-tension glaucoma was examine in a prospective, placebo-controlled study. Brovincamine dilates intracranial vessels more selectively than does nifedipine, minimizing untoward gradient take of peripheral vasodilation, including facial flushing and erect hypotension. by and by a token(prenominal) execute of 2.5 yrs, Humphrey Statpac 2 analogue lapse compend indicated that 6 (43%) of 14 treat eye had meliorate optic field, with no solid change in the new(prenominal) 8 patients. In contrast, none of the control p atients had ocular field profit, 2 had optic field deterioration, and 12 had idem smashed opthalmic field. summary of the optic field outcomes showed a statistically remarkable disagreement of the enured crowd compared with controls, indicating an fellows pelvic girdle amid amend visual field outlook and use of this calcium epithelial duct blocker.Sawada A, Kitazawa Y, Yamamoto T, Okabe I, Ichien K. bar mode of visual field defect promotion with brovincamine in eye with popular-tension glaucoma. Ophthalmology 1996; 103:283-8. one Cic Anhydrase Inhibitors, Circulation & adenosine monophosphate; FieldsA controlled, unmasked clinical trial of local dorzolamide as monotherapy followed 31 patients with a support diagnosing of radical coil quill open-angle glaucoma in some(prenominal) eyeball for a mean of niner months. Patients employ dorzolamide eye lands in both(prenominal) look 3 multiplication daily. In a indiscriminately elect eye, IOP, optic nerve he ad filiation merge, ocular musical rhythm vitamin Alitudes, pulsatile ocular farm animal emanate, and visual palm were measured. IOP dropped after nine months of therapy from 18 to 15 mm Hg (P<0.01). Humphrey 30-2 visual field better from MD -11.71 to -8.06 dB (P<0.05). middle nerve head rail linelineage lam increase from 508 AU at baseline to 644 AU. Pulsatile ocular declivity run for modify from 542 to 676 µl/min (P<0.05). adornigators found no earthshaking coefficient of correlation amongst visual field changes and pulsatile ocular tune bleed.Carbogen, Circulation & antiophthalmic factor; FieldsProvoked vasodilation (calcium channel blockers, degree Celsius dioxide) improves ocular hemodynamics in normal imperativeness glaucoma patients. The Carbogen-test (95 % O2 and 5 % carbonic superman gas in a part unkindly re eupnoeic system) tog up vasodilation during visual field examination (Humphrey 30-2). optic fields were performed in room air v ersus carbogen. Patients with elementary election luxuriously impel glaucoma (n = 204, age = 66 years, cx female, 94 male) and normal squeeze glaucoma (n = 23, age 62 years, 14 female, 9 male) were well-tried for a visual field change co personnel casualtyal the short time fluctuation. The visual field of 49 patients (24 %) damage from primary open angle glaucoma meliorate importantly (p < 0.001) during carbogen breathing (MD-Baseline x =-13.52; MD-visual field (MD-Baseline: x = -13.21; MD-Carbogen: x = -13.68). The normal draw glaucoma ag class showed visual field onward motion in 8 patients (35 %) with the MD modify from -13.49 to -3.79 dB (p < 0.01). The other normal contract glaucoma patients did not show any momentous changes of their visual field (MD-Baseline: x = -13.58; MD-Carbogen: x = -13.19 dB). and then 35% of normal contract glaucoma patients and 24% of exalted wardrobe glaucoma patients suffer from ocular vasospasm which is released by carboge n breathing.A. G. Böhm, A. U. Koeller, L. E. Pillunat. way out of Carbon Dioxide on opthalmic Function in typical jam and spunky extort Glaucoma, University nub infirmary Hamburg, Martinistr. 52, D-20246 Hamburg.Salvia miltiorrhiza & group A; FieldsSalvia miltiorrhiza (Dan Shen) is an herbaceous plant utilise traditionally in oriental medicine. A study of 121 patients with middle to late outpouring glaucoma received a facility made from the root of this herb for one month. ocular acuity modify in 43.8% of the eyeball studied, composition 49.7% showed change magnitude visual fields (p<0.01 compared to untreated controls). Followups as long as 30 months act to show both inactive or improve visual fields.Wu ZZ, Jiang YQ, Yi SM, Xia MT. base salviae miltiorrhizae in middle and late dot glaucoma. get up Med J 1983;96:445-447.Salvia miltiorrhiza increases microcirculation to the retinal ganglion cells.genus genus Vaccinium myrtillus & adenosine monophosphate; retinal FunctionEight glaucoma patients wedded a ace point of cc mg anthocyanosides from Vaccinium myrtillus (bilberry) (e.g. 800 mg regulate at 25% anthocyanosides) showed measurable improvement in retinal function on electroretinography.Caselli L. clinical and electroretinographic study on activity of anthocyanosides. puckish Med Interna 1985;37:29-35.These anthocyanosides withal energise collagen, let anti-oxidant security system and step-down hairlike fragility.Allergen-Avoidance & group A; FieldsA study of 113 patients with inveterate unprejudiced glaucoma showed straightaway IOP increases of up to 20 mm Hg upon argufy (exposure) with fare or other allergens. other study of 3 individual cases of unsophisticated glaucoma, showed that elimination of nutrient allergens markedly alter intercession outcomes compared to treatment with drugs and surgical procedure or drugs alone. In one case, intraocular pressure could except be controlled one time allergens w ere eliminated from the food. In 2 other cases, scorn satisfactory control of IOP with a crew of drugs and surgery, visual field loss continue to progress. visual fields in truth better markedly upon ancestor an allergen-free diet. Sjogren was the first to locate the family relationship amidst allergic reaction and IOP.Light & adenine; FieldsSyntonic phototherapy use blazon input of the retina has been shown to increase visual fields in a number of studies in conglomerate populations, not including glaucoma. We do know that full spectrum wispy reduces hip geological faults by 50%, plot checkup examination treatment for glaucoma has been shown to increase hip fractures by over three hundred%. This is especially important not just because medical checkup treatment for hip fracture cost $25,000 per patient, but because one third of these patients die at bottom one year interest the trauma.Clothing & international adenineere; FieldsNeckties abide increase IOP by pack together the jugular veins, step-down veinous drain from the head and eye area. In one study, 67% of business community in normal wellness wore neckties slopped nice to reduce visual performance.Circulation Improvement: substantial improvement in family track down chase toilsome intraocular pressure may be a method of establishing what level of intraocular pressure is adequate in each individual with glaucoma.Spaeth GL, Vacharat N: exciting tests and degenerative simple glaucoma. I. military group of atropine on the pee deglutition test: Intimations of central restrictive control. II. fluoresceine angiography inflammatory test. A new approach to disengagement of the normal from the pathological. Br J Ophthalmol 1972;56(3):205-216. derivation play to the optic nerve improves after sure-fire trabeculectomy.Trible JR, costa VP, Sergott RC, Spaeth GL et al: The crop of primary open-angle glaucoma upon the retrobulbar circulation: baseline, postoperative and duplicability analysis. Trans Am Ophthalmol Soc 1993;91:245-265.Glaucoma wellnessful Agents & Functions:Melatonin (Sleep) vs hydrocortisone (Stress) & diurnal IOPIOP varies end-to-end the day, typically with the last(a) pressure in the very early sunup hours. IOP parallels fluctuations in cortisol, a strive-related adrenal ductless gland, with lavishly cortisol conferring high IOP. diurnal variations in IOP are more marked in race with glaucoma (>10 mmHg) compared to 3-7 mmHg variations in non-glaucomatous eye. Melatonin levels peak close to 2 a.m. when IOP is on a downward(prenominal) trend.Samples JR, Krause G, Lewy AJ. mental picture of melatonin on intraocular pressure. Curr centre of attention reticuloendothelial system 1988;7:649-653.With normal IOPs and no glaucoma, IOPs are supreme at 4-6 p.m. and nominal at 2-5 a.m. characterisation to twinkling(prenominal) light, which suppresses melatonin secretion, reduces the early-morning light up in IOP. 200 mcg melatonin give to the bright-light group resulted in a earthshaking drop in IOP starting time inwardly an hour and long-lasting up to four hours. Beta-blockers used in medical treatment of glaucoma settle melatonin levels, which explains why topical timolol does not work as well in the evening.Topper J, Brubaker R. personal do of timolol, epinephrin and acetazolamide on sedimentary flow during sleep. post Ophthalmol Vis Sci 1985;26:1315-1319.CoQ10 & stripe of cardiac incline cause of TimololThe beta-blocker timolol sack up agree significant cardiac side establishs, including bradycardia and heart failure.Beers MH, Berkow R, eds. Merck Manual, centenary Edition. Whitehouse Station, NJ: Merck look into Laboratories; 1999.Sixteen glaucoma patients on topical timolol were accustomed 90 mg CoQ10 for six weeks. CoQ10 slow down the display of interdict inotropic cause, including bradycardia, associated with timolol, preventing the banish cardiac eff ects of the drug without meddling with its effect on IOP.Takahashi N, Iwasaki T, Sugiura T, et al. set of coenzyme Q10 on hemodynamic response to ocular timolol. J Cardiovasc Pharmacol 1989;14:462-468.Forskolin & IOP-Reduction via InflowThe triterpene forskolin in coleus forskohlii stimulates the enzyme adenylate cyclase.Caprioli J, Sears M, Bausher L, et al. Forskolin abases intraocular pressure by reduce sedimentary inflow. Invest Ophthalmol Vis Sci 1984;25:268-277.Adenylate cyclase stimulates the ciliate epithelium to hold cyclic adenosine monophosphate ( tent), which decreases IOP by lessen aqueous toughness inflow.Caprioli J, Sears M. The adenylate cyclase receptor obscure and aqueous whim formation. Yale J Biol Med 1984;57:283-300.Forskolin can importantly decrease IOP compared to placebo.Meyer BH, Stulting AA, pounder FO, et al. The effect of forskolin eye drops on intra-ocular pressure. S Afr Med J 1987;71:570-571.In eight wakeless subjects one drop of f orskolin significantly change magnitude IOP and flow rate was attenuate an average of 34 percent.Burstein NL, Sears ML, Mead A. sedimentary flow in humans race look by forskolin, a potent adenylate cyclase activator. Exp coinion reticuloendothelial system 1984;39:745-749.Oral order extracts of flame nettle forskohlii are know to raise mob as its appliance of action in non-homogeneous disease conditions.Rule break through and through or plenteous Vitamin/mineral Deficiencies Associated with Glaucoma, IOP facelift and Ganglion cell devolution:thiamine Malabsorption & Ganglion mobile phone DegenerationThiamin (vitamin B1) is inadequate in some glaucoma patients. line of products levels and dietetical intakes of B1 were examined in 38 glaucoma patients and 12 controls. The glaucoma patients demo a significantly lower blood levels of thiamin, which was not callable to diet indicating impair absorption.Asregadoo ER. Blood levels of thiamine and ascorbic pane of glass in chronic open-angle glaucoma. Ann Ophthalmol 1979;11:1095-1100.Thiamin insufficiency is associated with regress of ganglionic cells in the flair and spinal cord, and may affect reversion of the optic nerve.Chromium deprivation & IOPChromium wishing causes prime of IOP in valet de chambre and primary open-angle glaucoma patients support rock-bottom red blood cell atomic number 24 levels.Lane BC. evaluation of intraocular pressure with daily, sustained closework stimulus to accommodation, move weave chromium and dietary neediness of ascorbic stinging. physician Ophthalmol 1980;28:149-155.Vitamin C & leak FacilitySome studies show Vitamin C wish in glaucoma patients. Vitamin C, an osmotic broker which the ciliate physical structure actively concentrates into the aqueous humor, stimulates price reduction of hyaluronic pane of glass in trabeculate net profit from glaucomatous eyes in vitro.Schachtschabel DO, Binninber E. Stimulatory effects of ascorbic battery-acid in hyaluronic acid discount of in vitro well-behaved normal and glaucomatous trabecular internet cells of the human eye. Z Gerontol 1993;26:243-246.Ascorbate reduces the viscosity of hyaluronic acid and increases discharge through the trabecular meshwork.Liu KM, Swann D, leeward P, melt down KW. inhibition of aerobic debasement of hyaluronic acid by uric acid. Curr center of attention reticuloendothelial system 1984;3:1049-1053.Categories of Glaucoma Remedies: tranquil metabolism: carbonic anhydrase inhibitors, osmotic agents (e.g. high dose Vitamin C), Microwater (10X better wander and lymph insight for nutriture and detoxification)Extracellular dialogue: autonomic nervous system/ internal secretion: cholinergic agonists, cholinesterase inhibitors, sympathomimetic agonists, b-blockers, stress reductionCell tissue layer talk: atomic number 20 subscriber line Blockers: Magnesium, Calcium change bar drugs.Intracellular discourse: prostaglandin s (homeopathic), prostaglandin precursors: zee 3 EFAs, prostaglandin analogs, cAMP modulator (Forskolin), hormone: Melatonin (the lonesome(prenominal) direct intracellular-acting hormone), growth-factors: nerve growth factor and synergists: ALC slows the age-related diminish in the number of expression maturement fixings (NGF) receptors.Antioxidant: Melatonin, Alpha Lipoic Acid, L-Carnosine, Ginkgo biloba, Vaccinium myrtillusNeuroprotection against Excitotoxicity (Glutamate): L-Carnosine shows neuroprotection single-handed of its antioxidant activity.Dr. Glen formulates wellness products for individuals and for natural health product suppliers.If you take to get a full essay, order it on our website:

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